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Monocytes are produced by the bone marrow from precursors called monoblasts, bipotent cells that differentiated from hematopoietic stem cells. [5] Monocytes circulate in the bloodstream for about one to three days and then typically migrate into tissues throughout the body where they differentiate into macrophages and dendritic cells.
In hematopoiesis, myeloid cells, or myelogenous cells are blood cells that arise from a progenitor cell for granulocytes, monocytes, erythrocytes, or platelets [1] [2] (the common myeloid progenitor, that is, CMP or CFU-GEMM), or in a narrower sense also often used, specifically from the lineage of the myeloblast (the myelocytes, monocytes, and ...
These cords contain half of the mouse body's monocytes as a reserve so that, after tissue injury, these monocytes can move in and aid locally sourced monocytes in wound healing. [ 1 ] Erythrocytes pass through the cords of Billroth before entering the sinusoids.
The monoblast is the first stage of monocyte-macrophage maturation. The developmental stages of the monoblast are: CFU-GM (pluripotential hemopoietic stem cell or hemocytoblast) -> monoblast -> promonocyte-> monocyte-> macrophage/dendritic cell. During their development, monocytes are present in large packs in all of the lymph nodes in the body ...
Monocytes, the largest type of white blood cell, share the "vacuum cleaner" (phagocytosis) function of neutrophils, but are much longer lived as they have an extra role: they present pieces of pathogens to T cells so that the pathogens may be recognized again and killed. This causes an antibody response to be mounted.
A comprehensive diagram of human hematopoiesis. Granulopoiesis consists of 5 stages, in which the myeloblast is the first recognizable cell. Next in the differentiation sequence is the monoblast and the promyelocyte, which can develop into one of three different precursor cells: the neutrophilic, basophilic or eosinophilic myelocyte.
The first stage of the myeloid lineage is a granulocyte - monocyte progenitor (GMP), still an oligopotent progenitor, which then develops into unipotent cells that will later on form a population of granulocytes, as well as a population of monocytes. The first unipotent cell in granulopoiesis is a myeloblast. [5]
Diagram showing the development of different blood cells from haematopoietic stem cell to mature cells. Haematopoiesis (/ h ɪ ˌ m æ t ə p ɔɪ ˈ iː s ɪ s, ˌ h iː m ə t oʊ-, ˌ h ɛ m ə-/; [1] [2] from Ancient Greek αἷμα (haîma) 'blood' and ποιεῖν (poieîn) 'to make'; also hematopoiesis in American English, sometimes h(a)emopoiesis) is the formation of blood cellular ...