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58205 Ensembl ENSG00000197646 ENSMUSG00000016498 UniProt Q9BQ51 Q9WUL5 RefSeq (mRNA) NM_025239 NM_021396 RefSeq (protein) NP_079515 NP_067371 Location (UCSC) Chr 9: 5.51 – 5.57 Mb Chr 19: 29.39 – 29.45 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Programmed cell death 1 ligand 2 (also known as PD-L2, B7-DC) is a protein that in humans is encoded by the PDCD1LG2 gene. PDCD1LG2 ...
PDL2 or PDCD1LG2 (Programmed Cell Death 1 Ligand 2); on Dendritic cells, Macrophages etc. Ligand for PD-1 (CD279) CD274: PDL1 or PDCD1L1 (Programmed Cell Death 1 Ligand 1); expressed on T cells, NK cells, macrophages, myeloid DCs, B cells, epithelial cells, and vascular endothelial cells and others. Ligand for PD1 (CD279) and also CD80 (B7-1).
The Immunologic Constant of Rejection (ICR), is a notion introduced by biologists to group a shared set of genes expressed in tissue destructive-pathogenic conditions like cancer and infection, along a diverse set of physiological circumstances of tissue damage or organ failure, including autoimmune disease or allograft rejection. [1]
MHC class I and II proteins are required for immune cells to identify and attack them. The neoplastic B cells in PT-DLBCL also show gains and amplifications of CD274 and PDCD1LG2, which are the genes for the pro-death ligands, PDL1 and PDL2, respectfully. Overexpression of these ligand proteins inhibits the immune responses of various cell types.
pdcd1lg2 From an alternative name : This is a redirect from a title that is another name or identity such as an alter ego, a nickname, or a synonym of the target, or of a name associated with the target.
B7 is a type of integral membrane protein found on activated antigen-presenting cells (APC) that, when paired with either a CD28 or CD152 surface protein on a T cell, can produce a costimulatory signal or a coinhibitory signal to enhance or decrease the activity of a MHC-TCR signal between the APC and the T cell, respectively.
29126 60533 Ensembl ENSG00000120217 ENSMUSG00000016496 UniProt Q9NZQ7 Q9EP73 RefSeq (mRNA) NM_001314029 NM_001267706 NM_014143 NM_021893 RefSeq (protein) NP_001254635 NP_001300958 NP_054862 NP_068693 Location (UCSC) Chr 9: 5.45 – 5.47 Mb Chr 19: 29.34 – 29.37 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Programmed death-ligand 1 (PD-L1) also known as cluster of differentiation ...
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