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Isozyme. 31 languages. ... The enzyme lactate dehydrogenase is a tetramer made of two different sub-units, the H-form and the M-form.
The M2 isozyme of pyruvate kinase can form tetramers or dimers. Tetramers have a high affinity for PEP, whereas, dimers have a low affinity for PEP. Enzymatic activity can be regulated by phosphorylating highly active tetramers of PKM2 into an inactive dimers. [4] The PKM gene consists of 12 exons and 11 introns.
Pyruvate kinase isozymes M1/M2 (PKM1/M2), also known as pyruvate kinase muscle isozyme (PKM), pyruvate kinase type K, cytosolic thyroid hormone-binding protein (CTHBP), thyroid hormone-binding protein 1 (THBP1), or opa-interacting protein 3 (OIP3), is an enzyme that in humans is encoded by the PKM2 gene.
This 85-kDa protein is one of two subunit types that comprise the seven tetrameric PFK isozymes. [6] [7] The muscle isozyme is composed solely of PFKM.[6] [8] [9] The liver PFK (PFK-5) contains solely the second subunit type, PFKL, while the erythrocyte PFK includes five isozymes composed of different combinations of PFKM and PFKL.
The composition of the PFK1 tetramer differs according to the tissue type it is present in. For example, mature muscle expresses only the M isozyme, therefore, the muscle PFK1 is composed solely of homotetramers of M4. The liver and kidneys express predominantly the L isoform.
This isozyme is a tetramer of identical 54-kD subunits. [7] References External links. Human ALDH9A1 genome location and ALDH9A1 gene details page ...
Each isozyme is a heterotetramer that is composed of two alpha subunits, one beta subunit, and one gamma subunit. The protein encoded by this gene is the beta subunit of one isozyme of NAD(+)-dependent isocitrate dehydrogenase. Three alternatively spliced transcript variants encoding different isoforms have been described for this gene.
67834 Ensembl ENSG00000166411 ENSMUSG00000032279 UniProt P50213 Q9D6R2 RefSeq (mRNA) NM_005530 NM_029573 RefSeq (protein) NP_005521 NP_083849 Location (UCSC) Chr 15: 78.13 – 78.17 Mb Chr 9: 54.49 – 54.51 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial (IDH3α) is an enzyme that in humans is encoded by the IDH3A gene ...