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Infections of the hepatitis C virus (HCV) in children and pregnant women are less understood than those in other adults. Worldwide, the prevalence of HCV infection in pregnant women and children has been estimated to 1-8% and 0.05-5% respectively. [1]
Worldwide the prevalence of hepatitis C virus infection in pregnant women and children has been estimated to be 1–8% and 0.05–5% respectively. [153] The vertical transmission rate has been estimated to be 3–5% and there is a high rate of spontaneous clearance (25–50%) in the children.
The hepatitis C virus (HCV) [3] is a small (55–65 nm in size), enveloped, positive-sense single-stranded RNA virus of the family Flaviviridae. The hepatitis C virus is the cause of hepatitis C and some cancers such as liver cancer ( hepatocellular carcinoma , abbreviated HCC) and lymphomas in humans.
Human immunodeficiency virus (HIV) and hepatitis C virus (HCV) co-infection is a multi-faceted, chronic condition that significantly impacts public health.According to the World Health Organization (WHO), 2 to 15% of those infected with HIV are also affected by HCV, increasing their risk of morbidity and mortality due to accelerated liver disease.
[166] [167] In a recent study by the WHO, the likelihood of being infected with hepatitis C virus was six times greater in those who also had HIV. [167] The prevalence of HIV-HCV co-infection worldwide was estimated to be 6.2% representing more than 2.2 million people. [167] Intravenous drug use was an independent risk factor for HCV infection ...
One of the most common risk factors observed is infection with the Hepatitis C virus. [11] One review of a collection of PCT studies noted Hepatitis C infection in 50% of documented cases of PCT. Additional risk factors include alcohol use disorder, excess iron (from iron supplements as well as cooking on cast iron skillets), and exposure to ...
In addition to HIV, HBV, and HCV, some sexually transmitted infections (STIs) can be transmitted to uninfected individuals due to the risky injection practices. [8] According to CDC, in 2013, sharing syringes was the cause of HIV infection in 3,096 out of the 47,352 patients who were newly diagnosed with the disease in the United States. [2]
One general mechanism, increased DNA damage, is shared by some of the major liver diseases, including infection by hepatitis B virus or hepatitis C virus, heavy alcohol consumption, and obesity. [24] Viral infection by hepatitis B virus, or hepatitis C virus causes an increase of reactive oxygen species.
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