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Specific-pathogen-free (SPF) is a term used for laboratory animals that are guaranteed free of particular pathogens. Use of SPF animals ensures that specified diseases do not interfere with an experiment. For example, absence of respiratory pathogens such as influenza is desirable when investigating a drug's effect on lung function.
Between the 1950s and 1970s, germ-free models were used to study the effects of the absence of bacteria on host organism metabolism and physiology, which later evolved into intentionally infecting germ-free organisms with specific microorganisms to investigate their functions and other questions relating to the biomedical field. [9]
This process uses a non-germ-free mother which is sacrificed and sterilized before the pups' birth. After the cesarean birth, the pups must then be transferred to a sterile incubator with a germ-free mother for feeding and growth. [9] [10] These methods are only required for the generation of a germ-free mouse line. Once a line is generated ...
Dr. Leana Wen: I would approach this question by thinking about whether what you would do for yourself or your sick loved one would change if you knew the specific pathogen. Your actions would ...
Germfree mice and specific pathogen free (SPF) mice are helpful in addressing some of the issues, but inadequate in many areas. Germfree mice are not a good representation of normal mice, with issues of enlarged cecum, low reproductive rates, poorly developed immune system, and reduced health. SPF mice still contain varying microbiota, just ...
Specific-pathogen-free, laboratory animals known to be without pathogens; Superplastic forming, of sheet metal; Space Power Facility, a NASA test facility; S-phase-promoting factor, in biology; Formal spectrum of a ring, a construction in algebraic geometry; Spray polyurethane foam, a building insulation material; Spruce-pine-fir, mixed ...
The role of P. gingivalis in periodontitis is studied using specific pathogen-free mouse models of periodontal infections. In these models, P. gingivalis inoculation causes significant bone loss, which is a significant characteristic of the disease.
A scanning electron microscope image of a single human lymphocyte. The adaptive immune system, AIS, also known as the acquired immune system, or specific immune system is a subsystem of the immune system that is composed of specialized cells, organs, and processes that eliminate pathogens specifically.