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Trifluoromethyl group covalently bonded to an R group. The trifluoromethyl group is a functional group that has the formula-CF 3. The naming of is group is derived from the methyl group (which has the formula -CH 3), by replacing each hydrogen atom by a fluorine atom. Some common examples are trifluoromethane H– CF 3, 1,1,1-trifluoroethane H ...
In asymmetric trifluoromethylation the trifluoromethyl group is added to the substrate in an enantioselective way. [ 74 ] [ 75 ] Ruppert's reagent has been used for this purpose in an asymmetric induction approach to functionalise chiral amino acid derivates, [ 76 ] saccharides , [ 77 ] and steroids .
Trifluoromethyltrimethylsilane (known as Ruppert-Prakash reagent, TMSCF 3) is an organosilicon compound with the formula CF 3 Si(CH 3) 3.It is a colorless liquid. The compound is a reagent used in organic chemistry for the introduction of the trifluoromethyl group.
Triflate group Triflate anion. In organic chemistry, triflate (systematic name: trifluoromethanesulfonate), is a functional group with the formula R−OSO 2 CF 3 and structure R−O−S(=O) 2 −CF 3. The triflate group is often represented by −OTf, as opposed to −Tf, which is the triflyl group, R−SO 2 CF 3.
2,2,2-Trifluoroethanol is the organic compound with the formula CF 3 CH 2 OH. Also known as TFE or trifluoroethyl alcohol, this colourless, water-miscible liquid has a smell reminiscent of ethanol. Due to the electronegativity of the trifluoromethyl group, this alcohol exhibits a stronger acidic character compared to ethanol.
The trifluoromethyl cation is a molecular cation with a formula of CF + 3. It is a carbocation due to its positively charged carbon atom. It is part of the family of carbenium ions, with three fluorine atoms as substituents in place of its hydrogen atoms. [1]
4-Trifluoromethylbenzaldehyde is the organofluorine compound with the formula CF 3 C 6 H 4 CHO. Two other isomers are also known: 2-trifluoromethylbenzaldehyde and 3-trifluoromethylbenzaldehyde. These compounds are derivatives of benzaldehyde with trifluoromethyl substituents.
Many organofluorine compounds are generated from reagents that deliver perfluoroalkyl and perfluoroaryl groups. (Trifluoromethyl)trimethylsilane, CF 3 Si(CH 3) 3, is used as a source of the trifluoromethyl group, for example. [24] Among the available fluorinated building blocks are CF 3 X (X = Br, I), C 6 F 5 Br, and C 3 F 7 I.