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Phenylpropanolamine was first synthesized in the early 20th century, in or around 1910. [21] [11] It was patented as a mydriatic in 1913. [21] The pressor effects of phenylpropanolamine were characterized in the late 1920s and the 1930s. [21] Phenylpropanolamine was first introduced for medical use by the 1930s. [23] [11]
In addition, the use of Dexatrim or other OTC weight-loss supplements presents a possible factor in establishing disruptive eating patterns, [21] increases the risk that individuals will use these OTC supplements in lieu of seeking proper medical and nutritional consultation, [20] and presents increased psychological risks associated with ...
This is a list of adrenergic drugs. These are pharmaceutical drugs , naturally occurring compounds and other chemicals that influence the function of the neurotransmitter epinephrine (adrenaline). Receptor ligands
Medications such as clonidine and dexmedetomidine target pre-synaptic auto receptors, therefore leading to an overall decrease in norepinephrine which clinically can cause effects such as sedation, analgesia, lowering of blood pressure and bradycardia. There is also low quality evidence that they can reduce shivering post operatively.
4-Coumaroyl-CoA is the central biosynthetic precursor to phenylpropanoids (shown in protonated state) Phenylalanine Tyrosine. The phenylpropanoids are a diverse family of organic compounds that are biosynthesized by plants from the amino acids phenylalanine and tyrosine in the shikimic acid pathway. [1]
Propanolamines are a class of chemical compounds, many of which are pharmaceutical drugs. They are amino alcohols that are derivatives of 1-amino-2-propanol. [1] Propanolamines include: Acebutolol; Atenolol; Betaxolol; Bisoprolol; Metoprolol; Nadolol; Penbutolol; Phenylpropanolamine; Pindolol; Practolol; Propranolol; Ritodrine; Timolol
Polypharmacy is most commonly defined as the use of five or more medications daily by an individual. [6] However, the definition of polypharmacy is still debated and can vary from two to 11 concurrent medications. [6] Any drug: Cannabis: Amp joint [7] Any drug: Nicotine: Cooler [5] Any β-Carboline containing plant (e.g. Banisteriopsis caapi or ...
[8] [10] The drug robustly and dose-dependently elevates brain norepinephrine and dopamine levels in animals. [8] Phentermine is more potent in its effects on norepinephrine than on dopamine and the drug shows only weak effects on serotonin.