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Docusate is the common chemical and pharmaceutical name of the anion bis(2-ethylhexyl) sulfosuccinate, also commonly called dioctyl sulfosuccinate (DOSS). [2] [3] [4]Salts of this anion, especially docusate sodium, are widely used in medicine as an emollient laxative and as stool softeners, by mouth or rectally. [1]
It is available as a generic medication. [1] [6] In 2022, it was the 280th most commonly prescribed medication in the United States, with more than 600,000 prescriptions. [9] [10] In 2022, the combination with docusate was the 261st most commonly prescribed medication in the United States, with more than 1 million prescriptions.
Emollient laxatives, also known as stool softeners, are anionic surfactants that enable additional water and fats to be incorporated in the stool, making movement through the bowels easier. Properties. Site of action: small and large intestines; Onset of action: 12–72 hours; Examples: Docusate (Colace, Diocto), Gibs-Eze [3]
Stool softener laxatives: Colace ... Stimulant laxatives: Dulcolax (bisacodyl) stimulates intestinal muscles, causing them to contract and move the stool through the digestive tract.
Pharma giant Sanofi said its over-the-counter laxative, Dulcolax, is facing supply constraints. “Over the past few months, we have seen unprecedented demand for Dulcolax products," a Sanofi ...
Macrogol 4000, pharmaceutical quality. Macrogol 3350, often in combination with electrolytes, is used for short-term relief of constipation as well as for long-term use in constipation of various causes, including in multiple sclerosis and Parkinson's disease patients (an often-overlooked non-motor symptom) as well as constipation caused by pharmaceutical drugs such as opioids and ...