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Hereditary cancer syndromes underlie 5 to 10% of all cancers and there are over 50 identifiable hereditary forms of cancer. [5] Scientific understanding of cancer susceptibility syndromes is actively expanding: additional syndromes are being found, [6] the underlying biology is becoming clearer, and genetic testing is improving detection, treatment, and prevention of cancer syndromes. [7]
E-M215 or E1b1b, formerly known as E3b, is a major human Y-chromosome DNA haplogroup.E-M215 has two basal branches, E-M35 and E-M281. E-M35 is primarily distributed in North Africa and the Horn of Africa, and occurs at moderate frequencies in the Middle East, Europe, and Southern Africa.
E-P147 includes most of the subclades found in E-M96.The two branches of E-P147 have different distributions; while the less common branch, Haplogroup E-M132, has more of a distribution within West Africa, the more common branch, E-P177, can be found widely distributed with high frequency throughout Africa and to a lesser extent in the Middle East and Europe.
Haplogroup E-P2, also known as E1b1, is a human Y-chromosome DNA haplogroup.E-P2 has two basal branches, E-V38 and E-M215.E-P2 had an ancient presence in the Levant; presently, it is primarily distributed in Africa where it may have originated, and occurs at lower frequencies in the Middle East and Europe.
Haplogroup E is found throughout Maritime Southeast Asia. [4] It is nearly absent from mainland East Asia, where its sister group M9a (also found in Japan) is common. [4] [6] In particular, it is found among speakers of Austronesian languages, and it is rare even in Southeast Asia among speakers of other language families.
Haplogroup E-M2, also known as E1b1a1-M2, is a human Y-chromosome DNA haplogroup.E-M2 is primarily distributed within Africa followed by West Asia. More specifically, E-M2 is the predominant subclade in West Africa, Central Africa, Southern Africa, and the region of the African Great Lakes; it also occurs at moderate frequencies in North Africa, and the Middle East.
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