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Carbidopa/levodopa, also known as levocarb and co-careldopa, is the combination of the two medications carbidopa and levodopa. [6] It is primarily used to manage the symptoms of Parkinson's disease, but it does not slow down the disease or stop it from getting worse. [6]
Existing preparations are carbidopa/levodopa (co-careldopa, trade names Sinemet, Pharmacopa, Atamet) and benserazide/levodopa (co-beneldopa, trade name Madopar). Levodopa has also been related to a dopamine dysregulation syndrome, which is a compulsive overuse of the medication, and punding. [5]
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Trade names include Sinemet, Pharmacopa, Atamet, and Stalevo. As a drug, it is used in the clinical treatment of Parkinson's disease and dopamine-responsive dystonia. l-DOPA has a counterpart with opposite chirality, d-DOPA. As is true for many molecules, the human body produces only one of these isomers (the l-DOPA form).
Levodopa is taken by mouth, by inhalation, through an intestinal tube, or by administration into fat (as foslevodopa). [3] Side effects of levodopa include nausea, the wearing-off phenomenon, dopamine dysregulation syndrome, and levodopa-induced dyskinesia, among others. [3]
As Kim Yawitz, R.D., puts it, most people take vitamins and supplements because they want to be healthier, but taking the wrong ones together can do more harm than good.
Here are seven supplement combinations you should not take together or should be careful about combining. Related: 7 Things You Should Look for When Buying a Supplement, According to Dietitians 1.
Levodopa is a precursor to the neurotransmitter dopamine, which is administered to increase its levels in the central nervous system.However, most levodopa is decarboxylated to dopamine before it reaches the brain, and since dopamine is unable to cross the blood–brain barrier, this translates to little therapeutic gain with strong peripheral side effects.