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The De Simone Formulation is a probiotic formula and manufacturing method developed by Claudio De Simone. [1]The De Simone Formulation has been clinically studied for a variety of health conditions since the 1990s [2] but it has been researched the most for its efficacy in the medical management of chronic intestinal conditions including irritable bowel syndrome (IBS) [3] [4] and inflammatory ...
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The potential efficacy of probiotics to treat AAD depends on the probiotic strains and dosage. [ 100 ] [ 101 ] One review recommended for children L. rhamnosus or Saccharomyces boulardii at 5 to 40 billion colony-forming units/day, given the modest number needed to treat and the likelihood that adverse events are very rare. [ 94 ]
Lacticaseibacillus rhamnosus GG (ATCC 53103) is a strain of L. rhamnosus that was isolated in 1983 from the intestinal tract of a healthy human being; filed for a patent on 17 April 1985, by Sherwood Gorbach and Barry Goldin, [11] the 'GG' derives from the first letters of their surnames. [12]
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Probiotics are widely used and accepted in many countries in clinical practice. Paraprobiotics, the immobilised version of probiotics are gaining traction in recent years due to the concerns about the possibility of low tolerance of probiotics, especially in paediatric populations and in severely ill or immunocompromised patients. [ 6 ]