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Elagolix is used in the treatment of moderate to severe pain associated with endometriosis in premenopausal women. [1] Endometriosis is a condition in which the endometrium, the inner lining of the uterus, grows outside of the uterus into surrounding tissues and causes symptoms such as pelvic pain and infertility. [13]
It can also cause depression or depressive symptoms and anxiety in some individuals. [ 25 ] [ 26 ] Long-term side effects include Cushing's syndrome , steroid dementia syndrome , [ 27 ] truncal weight gain, glaucoma and cataracts , diabetes mellitus type 2 , and depression upon dose reduction or cessation. [ 28 ]
Fibroids are benign (non-cancerous) muscle tumors of the uterus that can cause heavy menstrual bleeding, pain, bowel or bladder problems and infertility. [2] Some women may not experience any symptoms, but many do, including heavy bleeding with periods. [2] Fibroids can occur at any age but are most common in women 35 to 49 years of age. [2]
The typical adult gains an average of 1 to 2 pounds per year, which over time, can contribute to obesity. This weight gain can be driven by physical inactivity, stress, poor sleep and poor food ...
A systematic review published in the journal Obesity Reviews in 2019 found that just about all of the widely-used medications for depression resulted in long-term weight gain, with the exception ...
Many antipsychotic drugs and mood stabilizers can cause patients to gain significant weight and contribute to diabetes and heart disease, the leading cause of death among adults with schizophrenia ...
Weight gain [18] There has been a study that suggests antipsychotics are associated with possible cortical reconfiguration and gray matter loss, [ 19 ] but correlational data also suggests patients who consume antipsychotics, like people with schizophrenia , tend to engage in unhealthy habits like smoking which may exacerbate gray matter loss.
The term "steroid dementia" was coined by Varney et al. (1984) in reference to the effects of long-term glucocorticoid use in 1,500 patients. [3] While the condition generally falls under the classification of Cushing's syndrome , the term "steroid dementia syndrome" is particularly useful because it recognizes both the cause of the syndrome ...