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Download as PDF; Printable version; In other projects Wikidata item; ... This is a list of antineoplastic agents used to treat cancer. Antineoplastic agents INN
Monomethyl auristatin E is an antimitotic agent which inhibits cell division by blocking the polymerisation of tubulin. The linker to the monoclonal antibody is stable in extracellular fluid, but is cleaved by cathepsin once the conjugate has entered a tumor cell, thus activating the antimitotic mechanism. [3] [4] Structure of a MMAE-MAB-conjugate.
An alkylating antineoplastic agent is an alkylating agent used in cancer treatment that attaches an alkyl group (C n H 2n+1) to DNA. [ 1 ] Since cancer cells, in general, proliferate faster and with less error-correcting than healthy cells, cancer cells are more sensitive to DNA damage—such as being alkylated.
Buthionine sulfoximine (BSO) is a sulfoximine derivative which reduces levels of glutathione and is being investigated as an adjunct with chemotherapy in the treatment of cancer. [1]
Generally, drugs outlined within the ATC code L01 should be included in this category. Please see WP:PHARM:CAT for more information. Wikimedia Commons has media related to Antineoplastic agents .
Cell-cycle nonspecific antineoplastic agents (CCNS) refer to a class of pharmaceuticals that act as antitumor agents at all or any phases of the cell cycle. [ 1 ] Alkylating antineoplastic agent and anthracyclins are two examples.
The precise mechanism by which altretamine exerts its anti-cancer effect is unknown but it is classified by MeSH as an alkylating antineoplastic agent. [5] This unique structure is believed to damage tumor cells through the production of the weakly alkylating species formaldehyde, a product of CYP450-mediated N-demethylation. Administered ...
Carboplatin is in the platinum-based antineoplastic family of medications and works by interfering with duplication of DNA. [3] [5] Carboplatin was developed as a less toxic analogue of cisplatin. [6] It was patented in 1972 and approved for medical use in 1989. [7] It is on the 2023 World Health Organization's List of Essential Medicines. [8]