Search results
Results From The WOW.Com Content Network
This page was last edited on 16 January 2025, at 18:41 (UTC).; Text is available under the Creative Commons Attribution-ShareAlike 4.0 License; additional terms may apply.
Anti-Cancer Agents in Medicinal Chemistry is a peer-reviewed academic journal covering the disciplines of medicinal chemistry and drug design relating to chemotherapeutic agents in cancer. It is published by Bentham Science Publishers and the editor-in-chief is Simone Carradori ( "G. d'Annunzio" University of Chieti-Pescara ).
An alkylating antineoplastic agent is an alkylating agent used in cancer treatment that attaches an alkyl group (C n H 2n+1) to DNA. [ 1 ] Since cancer cells, in general, proliferate faster and with less error-correcting than healthy cells, cancer cells are more sensitive to DNA damage—such as being alkylated.
The precise mechanism by which altretamine exerts its anti-cancer effect is unknown but it is classified by MeSH as an alkylating antineoplastic agent. [5] This unique structure is believed to damage tumor cells through the production of the weakly alkylating species formaldehyde, a product of CYP450-mediated N-demethylation. Administered ...
Cell-cycle nonspecific antineoplastic agents; Chemically linked Fab; Chemoimmunotherapy; Chemoprotective agent; Chemosensitizer; Chemotherapy; Chemotherapy-induced nausea and vomiting; Ciltacabtagene autoleucel; Copanlisib; Cytestrol acetate
Cell-cycle nonspecific antineoplastic agents (CCNS) refer to a class of pharmaceuticals that act as antitumor agents at all or any phases of the cell cycle. [ 1 ] Alkylating antineoplastic agent and anthracyclins are two examples.
Platinum-based antineoplastic drugs (informally called platins) are chemotherapeutic agents used to treat cancer. Their active moieties are coordination complexes of platinum . These drugs are used to treat almost half of people receiving chemotherapy for cancer.
Alkylating antineoplastic agents are a class of compounds that are used to treat cancer. In such case, the term alkyl is used loosely. For example, nitrogen mustards are well-known alkylating agents, but they are not simple hydrocarbons. In chemistry, alkyl is a group, a substituent, that is attached to other molecular fragments.