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Heart failure with preserved ejection fraction (HFpEF) is a form of heart failure in which the ejection fraction – the percentage of the volume of blood ejected from the left ventricle with each heartbeat divided by the volume of blood when the left ventricle is maximally filled – is normal, defined as greater than 50%; [1] this may be measured by echocardiography or cardiac catheterization.
N-terminal pro-BNP (NT-proBNP) is the favored biomarker for the diagnosis of heart failure, according to guidelines published 2018 by NICE in the UK. [3] Brain natriuretic peptide 32 (BNP) is another biomarker commonly tested for heart failure. [74] [6] [75] An elevated NT-proBNP or BNP is a specific test indicative of heart failure ...
[10] [11] [18] To investigate its use for heart failure in those with a preserved LVEF (HFpEF), Novartis funded the PARAGON-HF trial which was designed to investigate the use of sacubitril/valsartan in the treatment of HFpEF patients with a LVEF of 45% or more. Concluding in 2019, it failed to show significance for reducing hospitalisation ...
On Dec. 2, 2023, deputies responded to a distress call at a home in West End, N.C., where they found the toddler dead. Investigators believe the child was exposed to “elevated temperatures ...
Under his plea deal, Joseph Steven Jorgenson, 41, of Woodbury, is expected to be sentenced Feb. 28 to two 40-year terms for the deaths of Manijeh Starren in 2023 and Fanta Xayavong in 2021 ...
A drug trafficking investigation in Bogalusa, Louisiana, has led to the arrest of the city's mayor, Tyrin Truong, and several other people, police said Tuesday.
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