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If the tear duct is not cleared by the time the newborn is 1 year old, surgery may be required. [4] Postnatal measures include: Use of 1% tetracycline ointment, 0.5% erythromycin ointment, or 1-2% silver nitrate solution (Credé's method) into the eyes of babies immediately after birth. [6]
A review found that when erythromycin was given with certain oral contraceptives, there was an increase in the maximum serum concentrations and AUC of estradiol and dienogest. [32] [33] Erythromycin is an inhibitor of the cytochrome P450 system, which means it can have a rapid effect on levels of other drugs metabolised by this system, e.g ...
Credé prophylaxis is the practice of washing a newborn's eyes with a 2% silver nitrate solution to protect against neonatal conjunctivitis caused by Neisseria gonorrhoeae, thereby preventing blindness.
This pathogen is usually acquired during delivery, occurring in 30-40% of cases with known maternal infection. Additionally, untreated maternal gonorrhea may increase the risk of preterm delivery. The most common manifestation of gonococcal infection in a newborn is neonatal conjunctivitis , an infection of the eyes that presents with green ...
Occasionally erythromycin ophthalmic ointment is recommended. [20] Other antibiotics, such as chloramphenicol or amoxicillin may also be used. [ 21 ] Chloramphenicol is used successfully in many parts of the world, but contains a black box warning in the United States due to concerns about aplastic anemia , which on rare occasions can be fatal.
Figure 1.0 - Basic anatomical features of the human eye. Ophthalmic drug administration is the administration of a drug to the eyes, most typically as an eye drop formulation. Topical formulations are used to combat a multitude of diseased states of the eye. These states may include bacterial infections, eye injury, glaucoma, and dry eye. [1]
A medical professional administering nose drops Instillation of eye drops. A topical medication is a medication that is applied to a particular place on or in the body. Most often topical medication means application to body surfaces such as the skin or mucous membranes to treat ailments via a large range of classes including creams, foams, gels, lotions, and ointments. [1]
Bacitracin/polymyxin B (trade name Polysporin among others) is a topical antibiotic cream or ointment. [1] The active ingredients are polymyxin B, bacitracin and occasionally garamycin or gramicidin.