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Linaclotide, (sold under the brand name Linzess in the US and Mexico, and as Constella elsewhere) [6] is a drug used to treat irritable bowel syndrome with constipation and chronic constipation with no known cause.
Eluxadoline is a μ-and κ-opioid receptor agonist and δ-opioid receptor antagonist [12] that acts locally in the enteric nervous system, possibly decreasing adverse effects on the central nervous system. [13] [14]
A 2018 pooled analysis from three phase III, randomized, double-blind, placebo-controlled studies on usage for Opioid-Induced Constipation, found that the numbers of patients reporting adverse effects were similar in both the lubiprostone and placebo treatment groups for all opioid classes (P ≥ 0.125); however, gastrointestinal adverse ...
Ironwood Pharmaceuticals Provides Third Quarter 2012 Investor Update - Received FDA Approval of LINZESS™ (linaclotide) for Treatment of Adult Patients with IBS-C or CIC; Prepared for Commercial ...
Ironwood Pharmaceuticals Provides Second Quarter 2013 Investor Update Second quarter LINZESS ® (linaclotide) net product sales of $28.8 million, as reported by Forest Laboratories, Inc. CAMBRIDGE ...
But some research has noted rare but serious side effects of once-weekly, 2.4-milligram (mg) semaglutide injections, such as pancreatitis, acute kidney injury, gallbladder issues, and thyroid cancer.
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