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Acrocyanosis may be a sign of a more serious medical problem, such as connective tissue diseases and diseases associated with central cyanosis. Other causative conditions include infections , toxicities, antiphospholipid syndrome , cryoglobulinemia , neoplasms.
The body's network of blood vessels is also affected. Children with this disorder may experience rashes of tiny red spots caused by bleeding under the skin and blue discoloration in the hands and feet due to reduced oxygen in the blood (acrocyanosis). Chronic diarrhea is another common feature of ethylmalonic encephalopathy. [3]
Both of these conditions cause cyanosis, or a bluish discoloration of skin or mucous membranes. [4] Normally, oxygenated blood appears red and deoxygenated blood has more of a blue appearance. [5] In babies with low levels of oxygen or mixing of oxygenated and deoxygenated blood, the blood can have a blue or purple color, causing cyanosis. [6]
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Central cyanosis occurs due to decrease in arterial oxygen saturation (SaO2), and begins to show once the concentration of deoxyhemoglobin in the blood reaches a concentration of ≥ 5.0 g/dL (≥ 3.1 mmol/L or oxygen saturation of ≤ 85%). [4] This indicates a cardiopulmonary condition. [1] Causes of central cyanosis are discussed below.
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Mongolian spot is a congenital developmental condition—that is, one existing from birth—exclusively involving the skin.The blue colour is caused by melanocytes, melanin-containing cells, that are usually located in the surface of the skin (the epidermis), but are in the deeper region (the dermis) in the location of the spot. [6]
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