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Post-exposure prophylaxis, also known as post-exposure prevention (PEP), is any preventive medical treatment started after exposure to a pathogen in order to prevent the infection from occurring. It should be contrasted with pre-exposure prophylaxis, which is used before the patient has been exposed to the infective agent.
[45] [46] [104] With the exception of post-exposure prophylaxis (PEP), treatment guidelines do not call for the interruption of drug therapy once it has been initiated. [ 7 ] [ 44 ] [ 83 ] [ 104 ] Adverse effects
BHIVA produce guidelines which are accredited by the UK National Institute for Health and Care Excellence (NICE). [4] Guidelines produced by BHIVA include: Pre-exposure prophylaxis (PrEP) guidelines [5] Treatment of HIV-1 positive adults [6] Use of Vaccines in HIV-positive adults [7] Post-exposure prophylaxis (PEP) guidelines [8]
A course of antiretrovirals administered within 48 to 72 hours after exposure to HIV-positive blood or genital secretions is referred to as post-exposure prophylaxis (PEP). [144] The use of the single agent zidovudine reduces the risk of an HIV infection five-fold following a needle-stick injury. [144]
A course of antiretrovirals administered within 48 to 72 hours after exposure to HIV-positive blood or genital secretions is referred to as post-exposure prophylaxis. [52] The use of the single agent zidovudine reduces the risk of subsequent HIV infection fivefold following a needle stick injury. [52]
AZT has been used for post-exposure prophylaxis (PEP) in combination with another antiretroviral drug called lamivudine. Together they work to substantially reduce the risk of HIV infection following the first single exposure to the virus. [14] More recently, AZT has been replaced by other antiretrovirals such as tenofovir to provide PEP. [15]
In 2019, Gilead Sciences challenged the validity of patents granted to the United States after 2015 for using the drug combination for HIV PrEP and post-exposure prophylaxis (PEP). [41] [42] [43] In July 2024, The Biden administration appealed the jury finding that ruled in favor of Gilead Sciences verdict that the U.S. government's patents are ...
Beginning in January 2020, after California Governor Gavin Newsom signed Senate Bill 159 (SB159) in 2019, licensed pharmacists in California are authorized to initiate and dispense a 30 to 60 day supply of pre-exposure prophylaxis (PrEP) or the full course of post-exposure prophylaxis (PEP) without a doctor's prescription, given certain ...
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