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Melanocytes are melanin-producing neural crest-derived [3] cells located in the bottom layer (the stratum basale) of the skin's epidermis, the middle layer of the eye (the uvea), [4] the inner ear, [5] vaginal epithelium, [6] meninges, [7] bones, [8] and heart found in many mammals and birds. [9] Melanin is a dark pigment primarily responsible ...
Along the junction of the epidermis and the underlying dermis. [15] May be colored and slightly raised. [16] ICD10: D22 ICDO: M8740/0 Compound nevus Both the epidermis and dermis. [17] ICD10: D22 (ILDS D22.L14) ICDO: 8760/0 Intradermal nevus Within the dermis. A classic mole or birthmark. It typically appears as an elevated, dome-shaped bump on ...
Albinism occurs when melanocytes produce little melanin. This albino girl is from Papua New Guinea. In humans, melanin is the primary determinant of skin color. It is also found in hair, the pigmented tissue underlying the iris of the eye, and the stria vascularis of the inner ear.
This is an accepted version of this page This is the latest accepted revision, reviewed on 11 February 2025. "Skin pigmentation" redirects here. For animal skin pigmentation, see Biological pigment. Extended Coloured family from South Africa showing some spectrum of human skin coloration Human skin color ranges from the darkest brown to the lightest hues. Differences in skin color among ...
Both of these conditions originate from the same type of cell: the melanocyte. However, a melanocytic nevus is benign, and melanoma is malignant. Most melanocytic nevi never evolve into a cancer, with the lifetime risk for an individual nevus being 1 in 3000 for men and 1 in 11 000 for women. [5]
Melanocytes are found between the outer layer of the skin (the epidermis) and the next layer (the dermis). This early stage of the disease is called the radial growth phase, when the tumor is less than 1 mm thick, and spreads at the level of the basal epidermis. [ 41 ]
Mongolian spot is a congenital developmental condition—that is, one existing from birth—exclusively involving the skin.The blue colour is caused by melanocytes, melanin-containing cells, that are usually located in the surface of the skin (the epidermis), but are in the deeper region (the dermis) in the location of the spot. [6]
Micrograph of keratinocytes, basal cells and melanocytes in the epidermis Keratinocytes (stained green) in the skin of a mouse. Keratinocytes are the primary type of cell found in the epidermis, the outermost layer of the skin. In humans, they constitute 90% of epidermal skin cells. [1]