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Elliptocytes, also known as ovalocytes or cigar cells, are abnormally shaped red blood cells that appear oval or elongated, from slightly egg-shaped to rod or pencil forms. They have normal central pallor with the hemoglobin appearing concentrated at the ends of the elongated cells when viewed through a light microscope.
Normal red blood cells are round, flattened disks that are thinner in the middle than at the edges. A poikilocyte is an abnormally-shaped red blood cell. [1] Generally, poikilocytosis can refer to an increase in abnormal red blood cells of any shape, where they make up 10% or more of the total population of red blood cells.
One theory regarding dacrocyte formation is that red blood cells containing various inclusions undergo "pitting" by the spleen to remove these inclusions, and in the process, they can be stretched too far to return to their original shape. [2]
Hereditary spherocytosis is a genetically transmitted (autosomal dominant) form of spherocytosis, an auto-hemolytic anemia characterized by the production of red blood cells that are sphere-shaped rather than bi-concave disk shaped (donut-shaped), and therefore more prone to hemolysis. [41] Hereditary elliptocytosis: D58.1: 4172
[15] [53] With more severe iron-deficiency anemia, the peripheral blood smear may show hypochromic, pencil-shaped cells and, occasionally, small numbers of nucleated red blood cells. [57] The platelet count may be slightly above the high limit of normal in iron-deficiency anemia (termed a mild thrombocytosis ), but severe cases can present with ...
Hereditary elliptocytosis, also known as ovalocytosis, is an inherited blood disorder in which an abnormally large number of the person's red blood cells are elliptical rather than the typical biconcave disc shape. Such morphologically distinctive erythrocytes are sometimes referred to as elliptocytes or ovalocytes.
Red blood cells are the most abundant cell in the blood, accounting for about 40–45% of its volume. Red blood cells are circular, biconcave, disk-shaped and deformable to allow them to squeeze through narrow capillaries. They do not have a nucleus. Red blood cells are much smaller than most other human cells.
Acanthocytes, from peripheral blood, under light microscopy. Note the irregularly shaped, non-circular cells in the image. Acanthocyte (from the Greek word ἄκανθα acantha, meaning 'thorn'), in biology and medicine, refers to an abnormal form of red blood cell that has a spiked cell membrane, due to thorny projections.