Search results
Results From The WOW.Com Content Network
In pharmacology, GABA A receptor positive allosteric modulators, also known as GABAkines or GABA A receptor potentiators, [1] are positive allosteric modulator (PAM) molecules that increase the activity of the GABA A receptor protein in the vertebrate central nervous system. GABA is a major inhibitory neurotransmitter in the central nervous system.
Schematic diagram of a GABA A receptor protein ((α1) 2 (β2) 2 (γ2)) which illustrates the five combined subunits that form the protein, the chloride (Cl −) ion channel pore, the two GABA active binding sites at the α1 and β2 interfaces, and the benzodiazepine (BZD) allosteric binding site [20] Side view of the EM structure of the α1β3γ2 GABAA receptor.
The GABA receptors are a class of receptors that respond to the neurotransmitter gamma-aminobutyric ... Two separate genes on two chromosomes control GABA synthesis ...
The glutamate/GABA–glutamine cycle is a metabolic pathway that describes the release of either glutamate or GABA from neurons which is then taken up into astrocytes (non-neuronal glial cells). In return, astrocytes release glutamine to be taken up into neurons for use as a precursor to the synthesis of either glutamate or GABA. [2]
Harold Gaba, American businessman; Lester Gaba, a US sculptor, writer and retail display designer; Marianne Gaba, a US model; Milan Gába, a former Czechoslovak slalom canoeist; Millind Gaba, Indian musician and celebrity; Mo Gaba, American sports superfan and radio personality; Pierre Toura Gaba (1920–1998), a Chadian politician and diplomat
It serves as the precursor for the synthesis of the inhibitory gamma-aminobutyric acid (GABA) in GABAergic neurons. Its molecular formula is C 5 H 9 NO 4. Glutamic acid exists in two optically isomeric forms; the dextrorotatory L-form is usually obtained by hydrolysis of gluten or from the waste waters of beet-sugar manufacture or by fermentation.
[2] [3] [4] The pathway is a minor pathway in GABA synthesis compared to the main pathway in which GABA is synthesized from glutamate. [2] [3] [4] However, the pathway has been found to have an important physiological role in the brain, for instance in the production of GABA in the striatum and resultant inhibition of dopaminergic neurons in ...
[2] [3] [4] The pathway is a minor pathway in GABA synthesis compared to the main pathway in which GABA is synthesized from glutamate. [2] [3] [4] However, the pathway has been found to have an important physiological role in the brain, for instance in the production of GABA in the striatum and resultant inhibition of dopaminergic neurons in ...