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Serotonin (/ ˌ s ɛr ə ˈ t oʊ n ɪ n, ˌ s ɪər ə-/) [6] [7] [8] or 5-hydroxytryptamine (5-HT) is a monoamine neurotransmitter.Its biological function is complex, touching on diverse functions including mood, cognition, reward, learning, memory, and numerous physiological processes such as vomiting and vasoconstriction.
A serotonergic substance, medication, or receptor protein is one that affects neurotransmission pathways that involve serotonin, as follows: Serotonergic drugs Serotonin receptor agonists; Serotonin receptor antagonists; Serotonin reuptake inhibitors; Serotonin releasing agents; Serotonergic psychedelics; Serotonergic cells Serotonergic cell groups
The caudal serotonergic nuclei heavily innervate the spinal cord, medulla and cerebellum. In general, manipulation of the caudal nuclei(e.g. pharmacological, lesion, receptor knockout) that results in decreased activity decreases movement, while manipulations to increase activity cause an increase in motor activity.
The 5-HT 1B receptor as an example of a metabotropic serotonin receptor. Its crystallographic structure in ribbon representation. 5-HT receptors, 5-hydroxytryptamine receptors, or serotonin receptors, are a group of G protein-coupled receptor and ligand-gated ion channels found in the central and peripheral nervous systems.
Making It Enjoyable and Sustainable. As we age, a good night’s sleep becomes even more crucial for our overall health and well-being. However, maintaining consistent sleep patterns can become a ...
The 5-HT 3 receptor belongs to the Cys-loop superfamily of ligand-gated ion channels (LGICs) and therefore differs structurally and functionally from all other 5-HT receptors (5-hydroxytryptamine, or serotonin receptors) which are G protein-coupled receptors.
The 5-HT 7 receptor is a member of the GPCR superfamily of cell surface receptors and is activated by the neurotransmitter serotonin (5-hydroxytryptamine, 5-HT). [5] The 5-HT 7 receptor is coupled to G s (stimulates the production of the intracellular signaling molecule cAMP) [6] [7] and is expressed in a variety of human tissues, particularly in the brain, the gastrointestinal tract, and in ...
The serotonin transporter (SERT or 5-HTT) also known as the sodium-dependent serotonin transporter and solute carrier family 6 member 4 is a protein that in humans is encoded by the SLC6A4 gene. [5]