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Erythema contusiforme, when a subcutaneous hemorrhage (bleeding under the skin) occurs with an erythema nodosum lesion, causing the lesion to look like a contusion (bruise) Erythema nodosum migrans (also known as subacute nodular migratory panniculitis ), a rare form of chronic erythema nodosum characterized by asymmetrical nodules that are ...
TEN is a type of severe cutaneous adverse reactions (SCARs), together with SJS, a SJS/TEN, and drug reaction with eosinophilia and systemic symptoms. [5] It is called SJS when less than 10% of the skin is involved and an intermediate form with 10 to 30% involvement. [3] Erythema multiforme (EM) is generally considered a separate condition. [6]
The most common cause is certain medications such as lamotrigine, carbamazepine, allopurinol, sulfonamide antibiotics and nevirapine. [1] Other causes can include infections such as Mycoplasma pneumoniae and cytomegalovirus, or the cause may remain unknown. [2] [1] Risk factors include HIV/AIDS and systemic lupus erythematosus. [1]
Certain medications and other infections are also sometimes identified as causes of erythema multiforme, and while some experts doubt any true association with EM, [3] others disagree, citing the lack of any HSV DNA found in cases of drug-associated EM. [8] [9]
Stasis dermatitis, allergic contact dermatitis, acute irritant contact eczema and infective dermatitis have been documented as possible triggers, but the exact cause and mechanism is not fully understood. [7] Several other types of id reactions exist including erythema nodosum, erythema multiforme, Sweet's syndrome and urticaria. [3]
Erythema nodosum is a form of panniculitis characterised by tender red nodules, 1–10 cm, associated with systemic symptoms including fever, malaise, and joint pain. Nodules may become bluish-purple, yellowing, and green, and subside over a period of 2–6 weeks without ulcerating or scarring.
Chronic erythema nodosum (erythema nodosum migrans, subacute migratory panniculitis of Vilanova and Piñol, subacute nodular migratory panniculitis) Chronic erythema nodosum; Cold panniculitis (popsicle panniculitis) Congenital generalized lipodystrophy (Berardinelli–Seip syndrome) Cytophagic histiocytic panniculitis; Drug-induced lipodystrophy
The most common lesions are erythema nodosum, plaques, maculopapular eruptions, subcutaneous nodules, and lupus pernio. Treatment is not required, since the lesions usually resolve spontaneously in two to four weeks. Although it may be disfiguring, cutaneous sarcoidosis rarely causes major problems. [1]