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This means the nerve signals are interrupted and are slower. This causes muscle contractions to be irregular and fewer, resulting in an increased colon transit time. [12] The feces stay in the colon for a longer period of time, meaning that more water is absorbed. This leads to harder stools and therefore increases the symptoms of constipation.
The cause of multiple myeloma is unknown. [4] Risk factors include obesity, radiation exposure, family history, age and certain chemicals. [5] [11] [12] There is an increased risk of multiple myeloma in certain occupations. [13] This is due to the occupational exposure to aromatic hydrocarbon solvents having a role in causation of multiple ...
Primary or functional constipation is defined by ongoing symptoms for greater than six months not due to an underlying cause such as medication side effects or an underlying medical condition. [ 2 ] [ 19 ] It is not associated with abdominal pain, thus distinguishing it from irritable bowel syndrome . [ 2 ]
These causes are rare and constitute about 1% of all causes of hypercalcemia of malignancy. [22] Hypercalcemia of malignancy usually portends a poor prognosis, and the medial survival is 25–52 days of its development. [22] It has an incidence of 30% in those with cancer, and the prevalence is estimated to be about 2-3% in the United States. [22]
If possible, alternate medications should be prescribed that avoid the side effect of constipation. [citation needed] Given that all opioids can cause constipation, [6] it is recommended that any patient placed on opioid pain medications be given medications to prevent constipation before it occurs. Daily medications can also be used to promote ...
Monoclonal gammopathy, also known as paraproteinemia, is the presence of excessive amounts of myeloma protein or monoclonal gamma globulin in the blood. It is usually due to an underlying immunoproliferative disorder or hematologic neoplasms, especially multiple myeloma. It is sometimes considered equivalent to plasma cell dyscrasia.