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Butalbital/acetaminophen, sold under the brand name Butapap among others, is a combination medication used to treat tension headaches and migraine headaches. [1] [4] [5] It contains butalbital, a barbiturate and paracetamol (acetaminophen), an analgesic. [4] Versions also containing caffeine are sold under the brand name Fioricet among others. [6]
Butalbital is often combined with other medications, such as paracetamol (acetaminophen) (as Butalbital/acetaminophen) or aspirin, for the treatment of pain and headache. The various formulations combined with codeine are FDA -approved for the treatment of tension headaches .
The medication paracetamol (/ ˌ p ær ə ˈ s iː t ə m ɒ l / or / ˌ p ær ə ˈ s ɛ t ə m ɒ l /), also known as acetaminophen (/ ə ˌ s iː t ə ˈ m ɪ n ə f ɪ n / ⓘ), is sold around the world under a number of different brand names. Common brand names include Tylenol, Excedrin, Calpol, and Panadol.
Paracetamol, [a] or acetaminophen, [b] is a non-opioid analgesic and antipyretic agent used to treat fever and mild to moderate pain. [13] [14] [15] It is a widely available over-the-counter drug sold under various brand names, including Tylenol and Panadol. Paracetamol relieves pain in both acute mild migraine and episodic tension headache.
Analgesics containing butalbital compounded with aspirin, acetaminophen, and/or caffeine are widely used for the treatment of migraine and tension-type headache. The butalbital-containing compounds are efficacious in placebo-controlled trials among patients with episodic tension-type headaches.
Contains 250 mg acetaminophen, 250 mg aspirin and 65 mg caffeine. 1969: Excedrin PM – Excedrin PM is the first headache and sleeping pill combination product. [8] Contains 500 mg acetaminophen and 38 mg diphenhydramine citrate as a sleep aid. Those same active ingredients were later utilized several years later in the product Tylenol PM.
Products containing caffeine include coffee, tea, soft drinks ("colas"), energy drinks, other beverages, chocolate, [239] caffeine tablets, other oral products, and inhalation products. According to a 2020 study in the United States, coffee is the major source of caffeine intake in middle-aged adults, while soft drinks and tea are the major ...
Several such formulations have disappeared from over-the-counter status in drug store aisles and other retail outlets. One example is APC (aspirin, phenacetin, and caffeine) compound tablets common from the 1940s to 1983; because of harmful side effects of phenacetin, Anacin in the U.S. was reformulated to eliminate it; while Vincent's APC is ...