Search results
Results From The WOW.Com Content Network
SNX8 belongs to the sorting nexin family of proteins, which mainly contain two functional membrane-binding that allow SNXs to have different roles in endosomal sorting and protein trafficking thanks to its membrane curvature ability. [2] To begin with, SNX-PX is a distinct phosphoinositide (PI)-binding domain.
Sorting nexins either consist solely of a PX domain (e.g. SNX3) or have a modular structure made up of the PX and additional domains.. A subgroup of sorting nexins (comprising, in humans, SNX1, SNX2, SNX4, SNX5, SNX6, SNX7, SNX8, SNX9, SNX18, SNX30, SNX32 and SNX33) possess a BAR domain at their C-terminus.
File information Description Simplified scheme of DNA-triggered SNX8-mediated association of MITA and VPS34 and MITA activation, and its intracellular transport from RE to perinuclear microsomes.
In molecular biology, BAR domains are highly conserved protein dimerisation domains that occur in many proteins involved in membrane dynamics in a cell. The BAR domain is banana-shaped and binds to membrane via its concave face.
Main page; Contents; Current events; Random article; About Wikipedia; Contact us; Pages for logged out editors learn more
The retromer complex has been shown to mediate retrieval of various transmembrane receptors, such as the cation-independent mannose 6-phosphate receptor, functional mammalian counterparts of Vps10 such as SORL1, and the Wnt receptor Wntless. [14]
67804 Ensembl ENSG00000205302 ENSMUSG00000034484 UniProt O60749 Q9CWK8 RefSeq (mRNA) NM_003100 NM_001278199 NM_026386 NM_001357463 RefSeq (protein) NP_001265128 NP_003091 NP_080662 NP_001344392 Location (UCSC) Chr 5: 122.78 – 122.83 Mb Chr 18: 53.31 – 53.35 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Sorting nexin-2 is a protein that in humans is encoded by the SNX2 gene ...
71893 Ensembl ENSG00000196408 ENSMUSG00000019320 UniProt Q8NFA2 Q8VCM2 RefSeq (mRNA) NM_001267721 NM_144603 NM_172167 NM_172168 NM_027988 NM_001357836 RefSeq (protein) NP_001254650 NP_653204 NP_751907 NP_751908 NP_082264 NP_001344765 Location (UCSC) Chr 16: 1.98 – 1.98 Mb Chr 17: 24.92 – 24.92 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse NADPH oxidase organizer 1 is an enzyme ...