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Hypoadrenocorticism is an inherited disease in the following breeds (and therefore a higher proportion of dogs within these breeds are affected, compared to other breeds): [39] Bearded Collie; Nova Scotia Duck Tolling Retriever; Portuguese Water Dog; Standard Poodle; Some breeds are at increased risk of hypoadrenocorticism: Airedale Terrier [39]
The sodium–potassium pump a critical enzyme for regulating sodium and potassium levels in cells. Potassium is the main intracellular ion for all types of cells, while having a major role in maintenance of fluid and electrolyte balance. [1] [2] Potassium is necessary for the function of all living cells and is thus present in all plant and ...
Four genes have been identified as members of the K ATP gene family. The sur1 and kir6.2 genes are located in chr11p15.1 while kir6.1 and sur2 genes reside in chr12p12.1. The kir6.1 and kir6.2 genes encode the pore-forming subunits of the K ATP channel, with the SUR subunits being encoded by the sur1 (SUR1) gene or selective splicing of the sur2 gene (SUR2A and SUR2B).
The high permeability of glial cell membranes to potassium ions is a result of expression of high densities of potassium-selective channels with high open-probability at resting membrane potentials. Kir channels, potassium inward-rectifying channels, allow passage of potassium ions inward much more readily than outward. They also display a ...
Calcium-activated potassium channel subunit alpha-1 also known as large conductance calcium-activated potassium channel, subfamily M, alpha member 1 (K Ca 1.1), or BK channel alpha subunit, [5] is a voltage gated potassium channel encoded by the KCNMA1 gene and characterized by their large conductance of potassium ions (K+) through cell membranes.
The increased positive charge within the cell now causes the potassium channels to open. Potassium ions (K +) begin to move down the electrochemical gradient (in favor of the concentration gradient and the newly established electrical gradient). As potassium moves out of the cell the potential within the cell decreases and approaches its ...
K ir export surplus potassium into collecting tubules for removal in the urine, or alternatively may be involved in the reuptake of potassium back into the body. neurons and in heart cells: G-protein activated IRKs (K ir 3) are important regulators, modulated by neurotransmitters. A mutation in the GIRK2 channel leads to the weaver mouse mutation.
SK channels (small conductance calcium-activated potassium channels) are a subfamily of calcium-activated potassium channels. [1] They are so called because of their small single channel conductance in the order of 10 pS . [ 2 ]