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The mean steady-state volume is 162 L. Its initial half-life is 1.31 hours (30 mg dose) and 1.42 hours (60 mg dose), and its terminal half life is 18.7 hours (30 mg dose) and 21.9 hours (60 mg dose). [27] Metabolism. Dapoxetine is metabolized extensively in the liver and kidney by multiple enzymes such as CYP2D6, CYP3A4, and flavin ...
For example, in clinical trials of sildenafil, 28 percent of men reported headache (by far the most common side effect) at a dosage of 100mg, compared to just 16 percent of men who used 25mg and ...
Sildenafil is most commonly prescribed to be taken one time per day in doses between 25 and 100 mg for ED. Your healthcare provider will determine the best dosage for you based on a number of factors.
A single tablet of sildenafil can do that — typically, one dose is all that’s required to produce a firmer, longer-lasting hardness. Studies have shown a 70 to 80 percent success rate in ...
Chemical structure of sildenafil (Viagra), the prototypical PDE5 inhibitor. A phosphodiesterase type 5 inhibitor (PDE5 inhibitor) is a vasodilating drug that works by blocking the degradative action of cGMP-specific phosphodiesterase type 5 (PDE5) on cyclic GMP in the smooth muscle cells lining the blood vessels supplying various tissues.
Sildenafil, sold under the brand name Viagra among others, is a medication used to treat erectile dysfunction and pulmonary arterial hypertension. [4] [8] It is also sometimes used off-label for the treatment of certain symptoms in secondary Raynaud's phenomenon. [9] It is unclear if it is effective for treating sexual dysfunction in females. [8]
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