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Fluocinolone acetonide (0.01%)/Hydroquinone (4%)/ Tretinoin (0.05%) Cream is indicated for the short-term (up to 8 weeks) treatment of moderate to severe melasma of the face in the presence of measures for sun avoidance, including the use of sunscreens.
Hydroquinone is the compound most frequently used in skin-whitening products. Due to concerns about its side effects, it was almost banned by the FDA in 2006, as medical issues of carcinogenicity and reports of disfiguring ochronosis existed. [10] In the European Union hydroquinone has been banned in cosmetic creams since 2000. [11]
It can be used as a cream. [10] It is an antioxidant normally made by the body. [10] Whether or not it actually works is unclear as of 2019. [11] Due to side effects that may result from intravenous use, the government of the Philippines recommends against such use. [12] One 2017 review found tentative evidence of benefit of tranexamic acid in ...
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Depigmentation is the lightening of the skin or loss of pigment. Depigmentation of the skin can be caused by a number of local and systemic conditions. The pigment loss can be partial (injury to the skin) or complete (caused by vitiligo).