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In addition to other formulations, ciclopirox is used in lacquers for topical treatment of onychomycosis (fungal infections of the nails). A meta-analysis of the six trials of nail infections available in 2009 concluded that they provided evidence that topical ciclopirox had poor cure rates, and that amorolfine might be substantially more effective, but more research was required.
Topical ciclopirox results in a cure in 6% to 9% of cases. [2] [31] Ciclopirox when used with terbinafine appears to be better than either agent alone. [2] Although eficonazole, P-3051 (ciclopirox 8% hydrolacquer), and tavaborole are effective at treating fungal infection of toenails, complete cure rates are low. [36]
Pain, itchiness and burning sensations may occur following topical application of the medication. For patients using ciclopirox nail lacquers, redness of the skin around the nail and the proximal nail fold may occur, while a few of them develop nail disorders such as ingrown nails, changes in shape, and discoloration. [15]
Marketed as Curanail, Loceryl, Locetar, and Odenil, amorolfine is commonly available in the form of a nail lacquer, containing 5% amorolfine hydrochloride as the active ingredient. It is used to treat onychomycosis (fungal infection of the toe- and fingernails). Amorolfine 5% nail lacquer in once-weekly or twice-weekly applications was shown in ...
Nail polish (also known as nail varnish in British English or nail enamel) is a lacquer that can be applied to the human fingernails or toenails to decorate and protect the nail plates. The formula has been revised repeatedly to enhance its decorative properties, to be safer for the consumer to use, and to suppress cracking or peeling.
Mild onychomycosis sometimes responds to a combination of topical antifungal medication, sometimes applied as special medicinal nail lacquer, and periodic filing of the nail surface. For advanced onychomycosis, especially if more than one nail is infected, systemic medication (pills) is preferred. Home remedies are often used, although their ...