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Acetylcysteine is extensively liver metabolized, CYP450 minimal, urine excretion is 22–30% with a half-life of 5.6 hours in adults and 11 hours in newborns. [medical citation needed] Acetylcysteine is the N-acetyl derivative of the amino acid L-cysteine, and is a precursor in the formation of the antioxidant glutathione in the body.
N-Acetylcysteine amide (abbrev. NACA, AD4 and also known as acetylcysteinamide ) is an amide derivative of N -acetylcysteine that appears to have better blood–brain barrier permeability and bioavailability and a similar antioxidant capability.
In enzymology, a cysteine-S-conjugate N-acetyltransferase (EC 2.3.1.80) is an enzyme that catalyzes the chemical reaction acetyl-CoA + an S-substituted L-cysteine ⇌ {\displaystyle \rightleftharpoons } CoA + an S-substituted N-acetyl-L-cysteine
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N-acetyltransferase (NAT) is an enzyme that catalyzes the transfer of acetyl groups from acetyl-CoA to arylamines, arylhydroxylamines and arylhydrazines. [ 1 ] [ 2 ] [ 3 ] They have wide specificity for aromatic amines , particularly serotonin , and can also catalyze acetyl transfer between arylamines without CoA.
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