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Continuation of alcohol use will result in a higher risk of progression of liver disease and cirrhosis. In patients with acute alcoholic hepatitis, clinical manifestations include fever, jaundice, hepatomegaly , and possible hepatic decompensation with hepatic encephalopathy, variceal bleeding, and ascites accumulation.
The cause of cirrhosis can vary; alcohol and non-alcoholic fatty liver disease are main causes in western and industrialized countries, whereas viral hepatitis is the predominant cause in low and middle-income countries. [156] Cirrhosis is more common in men than in women. [158]
Alcoholic hepatitis is distinct from cirrhosis caused by long-term alcohol consumption. Alcoholic hepatitis can occur in patients with chronic alcoholic liver disease and alcoholic cirrhosis . Alcoholic hepatitis by itself does not lead to cirrhosis, but cirrhosis is more common in patients with long term alcohol consumption. [ 6 ]
Alcoholic liver disease is a hepatic manifestation of alcohol overconsumption, including fatty liver disease, alcoholic hepatitis, and cirrhosis. Analogous terms such as "drug-induced" or "toxic" liver disease are also used to refer to disorders caused by various drugs. [7]
Alcohol-related cirrhosis and pancreatitis Professional Musician, heavy metal vocalist Bonnie Pointer: 8 June 2020 (aged 69) Los Angeles, California: Cardiac arrest due to alcoholic liver disease and cirrhosis [3] Musician Patricia Minaldi: 1 December 2018 (aged 60) Lake Charles, Louisiana, United States Alcohol-related issues [4]
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Alcohol use is a major cause of preventable liver disease worldwide, and alcoholic liver disease is the main alcohol-related chronic medical illness. [6] Millions of people of all ages, from adolescents to the elderly, engage in unhealthy drinking. [7] In the United States, excessive alcohol use costs more than $249 billion annually. [8]
These cells are then replaced with scar tissue, leading to the condition called cirrhosis. Alcoholic liver disease is a major public health problem. For example, in the United States up to two million people have alcohol-related liver disorders. [153] Chronic heavy alcohol consumption can cause fatty liver, cirrhosis, and alcoholic hepatitis ...