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Within the therapeutic range there is a dose-response relationship. [25] A limited amount of evidence suggests lithium carbonate may contribute to the treatment of substance use disorders for some people with bipolar disorder.
Excessive levels of lithium can be harmful to the kidneys, and increase the risk of side effects in general. As a result, kidney function and blood levels of lithium are monitored in patients being treated with lithium. [2] Therapeutic plasma levels of lithium range from 0.5 to 1.5 mEq/L, with levels of 0.8 or higher being desirable in acute ...
The global estimated lifetime prevalence of bipolar disorder among adults range from 1 to 3 percent. [63] The annual incidence is estimated to vary from 0.3 to 1.2 percent worldwide. [ 23 ] According to the World Mental Health Survey Initiative, the lifetime prevalence of BP-II was found to be 0.4%, with a 12-month prevalence of 0.3%. [ 64 ]
John Frederick Joseph Cade AO [1] [2] [3] (18 January 1912 – 16 November 1980) was an Australian psychiatrist who in 1948 discovered the effects of lithium carbonate as a mood stabilizer in the treatment of bipolar disorder, then known as manic depression.
Lithium citrate was removed from 7Up in 1948 [5] after the Food and Drug Administration banned its use in soda. [6] Lithium citrate is used as a mood stabilizer and is used to treat mania, hypomania, depression and bipolar disorder. [7] It can be administered orally in the form of a syrup. [7]
The literature and research on the effects of psychosocial therapy on bipolar spectrum disorders are scarce, making it difficult to determine the efficacy of various therapies. [169] Mood stabilizers and atypical antipsychotics are commonly prescribed. [131] Among the former, lithium is the only compound approved by the FDA for children. [129]
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