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A retrovirus is a type of virus that inserts a DNA copy of its RNA genome into the DNA of a host cell that it invades, thus changing the genome of that cell. [2] After invading a host cell's cytoplasm, the virus uses its own reverse transcriptase enzyme to produce DNA from its RNA genome, the reverse of the usual pattern, thus retro (backward).
Revtraviricetes is a class of viruses that contains all viruses that encode a reverse transcriptase. [1] The group includes all ssRNA-RT viruses (including the retroviruses) and dsDNA-RT viruses. It is the sole class in the phylum Artverviricota, which is the sole phylum in the kingdom Pararnavirae. [2]
Orthoretrovirinae is a subfamily of viruses belonging to Retroviridae, a family of enveloped viruses that replicate in a host cell through the process of reverse transcription. [1] The subfamily currently includes six genera, of which Lentivirus contains the human immunodeficiency virus (HIV). These viruses cause a variety of tumors ...
Many reverse transcribing viruses, called retroviruses, in Riboviria are able to become integrated into the DNA of their host. These viruses become endogenized as part of their replication cycle. Namely, the viral genome is integrated into the host genome by the retroviral enzyme integrase, and viral mRNA is produced from that DNA.
The replication cycle of a retrovirus entails the insertion ("integration") of a DNA copy of the viral genome into the nuclear genome of the host cell.Most retroviruses infect somatic cells, but occasional infection of germline cells (cells that produce eggs and sperm) can also occur.
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