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Plasma cells, also called plasma B cells or effector B cells, are white blood cells that originate in the lymphoid organs as B cells [1] [2] and secrete large quantities of proteins called antibodies in response to being presented specific substances called antigens.
Monoclonal neoplasm (tumor): A single aberrant cell which has undergone carcinogenesis reproduces itself into a cancerous mass. Monoclonal plasma cell (also called plasma cell dyscrasia): A single aberrant plasma cell which has undergone carcinogenesis reproduces itself, which in some cases is cancerous.
Plasma is then removed from the blood by a cell separator. Three procedures are commonly used to separate the plasma from the blood cells, with each method having its own advantages and disadvantages: [6] Discontinuous flow centrifugation: One venous catheter line is required. Typically, a 300 ml batch of blood is removed at a time and ...
Through this antigen recognition and other cell interactions the B cell becomes activated and then divides and differentiates to become a plasma cell. The plasma cell, a B cell end product, is a very active antibody-secreting cell that helps protect the body by attacking and binding to antigen.
The niche for long-lived plasma cells is a subject of ongoing research, and while some aspects are understood, many questions remain. LLPCs are not inherently long-lived, and their survival relies on accessing specific pro-survival niches in the bone marrow, secondary lymphoid organs, mucosal tissues, and sites of inflammation.
The initial change, often involving one chromosome 14 translocation, establishes a clone of bone marrow plasma cells that causes the asymptomatic disorder MGUS, which is a premalignant disorder characterized by increased numbers of plasma cells in the bone marrow or the circulation of a myeloma protein immunoglobulin.
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These are not merely catchy sayings. Even though some sources may identify a phrase as a catchphrase, this list is for those that meet the definition given in the lead section of the catchphrase article and are notable for their widespread use within the culture. This list is distinct from the list of political catchphrases.