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For osteoporosis it is less preferred than bisphosphonates. [6] It is also used to reduce the risk of breast cancer in those at high risk. [6] It is taken by mouth. [6] Common side effects include hot flashes, leg cramps, swelling, and joint pain. [6] Severe side effects may include blood clots and stroke. [6] Use during pregnancy may harm the ...
For women who cannot or prefer not to use bisphosphonates, owing to gastrointestinal side effects, safety risks, or contraindications, selective estrogen receptor modulators (SERMs) like BZA may serve as a suitable alternative. SERMs may also benefit younger women who are at higher risk of fractures and require long-term treatment. [5]
The most common side effects include nausea, diarrhea, headache and eczema, but with only 2–4% increase compared with placebo group. Most of those side effects resolved within 3 months. Occasional severe allergic reactions have been reported including drug rash with eosinophilia and systemic symptoms (DRESS syndrome) [11]
[2] [3] [4] The use of thiazide diuretics, and gonadal hormone replacement has also been recommended, with the use of calcitonin, bisphosphonates, sodium fluoride or anabolic steroids also suggested in refractory cases. [5] Alternate day use may not prevent this complication. [6] It is also known as glucocorticoid-induced osteoporosis. [7]
Common side effects include fever, joint pain, high blood pressure, diarrhea, and feeling tired. [3] Serious side effects may include kidney problems, low blood calcium, and osteonecrosis of the jaw. [3] Use during pregnancy may result in harm to the baby. [3] It is in the bisphosphonate family of medications. [3]
Clodronic acid or clodronate disodium (Na 2 CH 2 Cl 2 O 6 P 2) is a first generation (non-nitrogenous) bisphosphonate.It is an anti-osteoporotic drug approved for the prevention and treatment of osteoporosis in post-menopausal women and men to reduce vertebral fractures, hyperparathyroidism, hypercalcemia in malignancy, multiple myeloma and fracture related pain because of its anti ...