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Rituximab, sold under the brand name Rituxan among others, is a monoclonal antibody medication used to treat certain autoimmune diseases and types of cancer. [18] It is used for non-Hodgkin lymphoma, chronic lymphocytic leukemia (in children and adults, but not recommended in elderly patients), rheumatoid arthritis, granulomatosis with polyangiitis, idiopathic thrombocytopenic purpura ...
In general, patients with acute ITP will only rarely have life-threatening bleeding. [54] Most patients ultimately have lower, but stable platelet counts, which are still hemostatic for the patient. Unlike children and adolescents, ITP is often chronic in adults, even after a splenectomy. [40]
Among patients with Evans syndrome, the prevailing causes of death were bleeding, infections, and hematological cancer. [ 4 ] It has been observed that there is a risk of developing other autoimmune problems and hypogammaglobulinemia , [ 30 ] in one cohort 58% of children with Evans syndrome had CD4-/CD8- T cells which is a strong predictor for ...
Thrombotic thrombocytopenic purpura (TTP) is a blood disorder that results in blood clots forming in small blood vessels throughout the body. [2] This results in a low platelet count, low red blood cells due to their breakdown, and often kidney, heart, and brain dysfunction. [1]
Anti-platelet autoantibodies in a pregnant woman with immune thrombocytopenic purpura will attack the patient's own platelets and will also cross the placenta and react against fetal platelets. Therefore, ITP is a significant cause of fetal and neonatal immune thrombocytopenia.
In this version the chemotherapy dose varies from cycle to cycle depending on the patient's ability to tolerate chemotherapy and the degree of neutropenia and thrombocytopenia observed in this patient after each cycle. This approach is called "dose-adjusted EPOCH", or "DA-EPOCH" (DA-EPOCH-R, DA-R-EPOCH or R-DA-EPOCH are used when rituximab is ...
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