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Side effects of droxidopa include headache, dizziness, nausea, and hypertension, among others. [2] Droxidopa is a synthetic amino acid precursor which acts as a prodrug to the neurotransmitter norepinephrine (noradrenaline). [4] Hence, it acts as a non-selective agonist of the α-and β-adrenergic receptors.
Norepinephrine, also known as noradrenaline and sold under the brand name Levophed among others, is a medication used to treat people with very low blood pressure. [2] It is the typical medication used in sepsis if low blood pressure does not improve following intravenous fluids . [ 3 ]
Norepinephrine is a catecholamine and a phenethylamine. [4] Its structure differs from that of epinephrine only in that epinephrine has a methyl group attached to its nitrogen, whereas the methyl group is replaced by a hydrogen atom in norepinephrine. [4]
Norepinephrine Epinephrine. A norepinephrine reuptake inhibitor (NRI, NERI) or noradrenaline reuptake inhibitor or adrenergic reuptake inhibitor (ARI), is a type of drug that acts as a reuptake inhibitor for the neurotransmitters norepinephrine (noradrenaline) and epinephrine (adrenaline) by blocking the action of the norepinephrine transporter (NET).
Side effects of phenylpropanolamine include increased heart rate and blood pressure, among others. [13] [14] [15] [12] Rarely, phenylpropanolamine has been associated with hemorrhagic stroke. [11] [16] [13] Phenylpropanolamine acts as a norepinephrine releasing agent, thereby indirectly activating adrenergic receptors.
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