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Opioids are a class of compounds that elicit analgesic (pain killing) effects in humans and animals by binding to the μ-opioid receptor within the central nervous system. The following table lists opioid and non-opioid analgesic drugs and their relative potencies .
However, studies have shown that non-opioid treatments for acute pain can be just as if not more effective than opioids at treating some acute pain conditions, which could be where VX-548 comes in.
A 2010 analysis in the Cochrane Database of Systematic Reviews found that less than 1 percent of patients taking opioids for chronic pain experienced addiction.
An analgesic drug, also called simply an analgesic, antalgic, pain reliever, or painkiller, is any member of the group of drugs used for pain management.Analgesics are conceptually distinct from anesthetics, which temporarily reduce, and in some instances eliminate, sensation, although analgesia and anesthesia are neurophysiologically overlapping and thus various drugs have both analgesic and ...
The WHO guidelines recommend prompt oral administration of drugs ("by the mouth") when pain occurs, starting, if the patient is not in severe pain, with non-opioid drugs such as paracetamol (acetaminophen) or aspirin, [1] with or without "adjuvants" such as non-steroidal anti-inflammatory drugs (NSAIDs) including COX-2 inhibitors.
opioids [60] more than two weeks of pain requiring opioid treatment is unusual [60] strain or pulled muscle NSAIDs, muscle relaxants [60] if inflammation is involved, NSAIDs may work better; short-term use only [60] minor pain after surgery paracetamol, NSAIDs [60] opioids rarely needed [60] severe pain after surgery opioids [60]
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