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Styrene oxide is a main metabolite of styrene in humans or animals, resulting from oxidation by cytochrome P450. It is considered possibly carcinogenic from gavaging significant amounts into mice and rats. [4] Styrene oxide is subsequently hydrolyzed in vivo to styrene glycol by epoxide hydrolase. [5]
Styrene is regarded as a "known carcinogen", especially in case of eye contact, but also in case of skin contact, of ingestion and of inhalation, according to several sources. [20] [33] [34] [35] Styrene is largely metabolized into styrene oxide in humans, resulting from oxidation by cytochrome P450.
The styrene monomer (from which polystyrene is made) is a cancer suspect agent. [109] Styrene is "generally found in such low levels in consumer products that risks aren't substantial". [110] Polystyrene which is used for food contact may not contain more than 1% (0.5% for fatty foods) of styrene by weight. [111]
Illustrative is the epoxidation of styrene with perbenzoic acid to styrene oxide: [12] The stereochemistry of the reaction is quite sensitive. Depending on the mechanism of the reaction and the geometry of the alkene starting material, cis and/or trans epoxide diastereomers may be formed. In addition, if there are other stereocenters present in ...
Further, the company produces base chemicals comprising ethylene, propylene, aromatics, and intermediate chemicals, such as styrene monomer, propylene oxide, solvents, detergent alcohols, ethylene ...
β-Nitrostyrene is an aromatic compound and a nitroalkene used in the synthesis of indigo dye [1] ... or by direct nitration of styrene using nitric oxide. [6]
as the first step of the aerobic styrene degradation pathway. [1] The product 2-phenyloxirane is also known as styrene oxide and can be converted by a styrene oxide isomerase (SOI) to obtain phenylacetaldehyde, which can be transformed into the key-intermediate phenylacetic acid by a phenylacetaldehyde dehydrogenase (PAD).
Styrene acrylonitrile resin (SAN) is a copolymer plastic consisting of styrene and acrylonitrile. It is widely used in place of polystyrene owing to its greater thermal resistance. The chains of between 70 and 80% by weight styrene and 20 to 30% acrylonitrile. [ 1 ]