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Styrene oxide has a chiral center and thus two enantiomers. It has been reported that the two enantiomers had different toxicokinetics and toxicity [citation needed]. It was reported that the (R)-styrene oxide was preferentially formed in mice, especially in the lung, whereas the (S)-styrene oxide was
Residents near Cleves are being urged to leave their homes Tuesday afternoon because a rail car is leaking styrene. What to know about the chemical.
Styrene is regarded as a "known carcinogen", especially in case of eye contact, but also in case of skin contact, of ingestion and of inhalation, according to several sources. [20] [33] [34] [35] Styrene is largely metabolized into styrene oxide in humans, resulting from oxidation by cytochrome P450.
The styrene monomer (from which polystyrene is made) is a cancer suspect agent. [109] Styrene is "generally found in such low levels in consumer products that risks aren't substantial". [110] Polystyrene which is used for food contact may not contain more than 1% (0.5% for fatty foods) of styrene by weight. [111]
Here's what the Drug & Poison Information Center at Cincinnati Children’s Hospital advises regarding returning home following the styrene leak.
Styrene is a flammable gas and can be fatal if inhaled. The chemical is also considered a probable human carcinogen that can damage organs, inflame lungs, and make it hard to breathe, according to ...
IARC group 2A agents are substances and exposure circumstances that have been classified as probable carcinogens by the International Agency for Research on Cancer (IARC). [1] This designation is applied when there is limited evidence of carcinogenicity in humans, as well as sufficient evidence of carcinogenicity in experimental animals .
Illustrative is the epoxidation of styrene with perbenzoic acid to styrene oxide: [12] The stereochemistry of the reaction is quite sensitive. Depending on the mechanism of the reaction and the geometry of the alkene starting material, cis and/or trans epoxide diastereomers may be formed. In addition, if there are other stereocenters present in ...