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Chromium(III) picolinate (also trivalent chromium) is a chemical compound with the formula Cr(C 5 H 4 N(CO 2)) 3, commonly abbreviated as CrPic 3. It is a bright-red coordination compound derived from chromium (III) and picolinic acid .
FDA concludes, however, that the existence of such a relationship between chromium picolinate and either insulin resistance or type 2 diabetes is highly uncertain." [ 29 ] In 2010, chromium(III) picolinate was approved by Health Canada to be used in dietary supplements.
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Trivalent chromium, or chromium(III), is an essential trace mineral in the human diet. [3] In some nutritional supplements, chromium(III) occurs as chromium(III) picolinate (in which chromium is bound to picolinic acid) or chromium(III) nicotinate (in which chromium is bound to nicotinic acid). Nicotinic acid is also known as the B vitamin niacin.
Chromium is a chemical element; it has symbol Cr and atomic number 24. It is the first element in group 6. It is a steely-grey, lustrous, hard, and brittle transition metal. [10] Chromium is valued for its high corrosion resistance and hardness.
Structure of Zn(picolinate) 2 (H 2 O) 2. Hydrogenation of picolinic acid gives piperidine-2-carboxylic acid, a precursor to the drug Mepivacaine. Picolinic acid is a bidentate chelating agent of elements such as chromium, zinc, manganese, copper, iron, and molybdenum in the human body. [5] [6] It is a substrate in the Mitsunobu reaction.