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RAS Mutations & Treatment Options
- Targeting RAS Mutations
Targeting RAS-Addicted PDAC
Targeting RAS Mutations
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PDAC Remains Highly Lethal
Current Treatment Falls Short
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RAS Mutations In PDAC
Impact Over 90% Of PDAC Patients
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Pancreatic cancer is among the most deadly forms of cancer globally, with one of the lowest survival rates. In 2015, pancreatic cancers of all types resulted in 411,600 deaths globally. [8] Pancreatic cancer is the fifth-most-common cause of death from cancer in the United Kingdom, [19] and the third most-common in the United States. [20]
Surgery may follow neoadjuvant chemotherapy, which aims to shrink the tumor and increase the likelihood of complete resection. [8] Post-operative death and complications associated with pancreaticoduodenectomy have become less common, with rates of post-operative mortality falling from 30 to 10% in the 1980s to less than 5% in the 2000s. [9]
Brain and pancreatic cancers have much lower median survival rates which have not improved as dramatically over the last forty years. [4] Indeed, pancreatic cancer has one of the worst survival rates of all cancers. Small cell lung cancer has a five-year survival rate of 4% according to Cancer Centers of America's Website. [5]
Survival after medical and surgical treatment of pancreatic adenocarcinoma. In: Beger HG, Matsuno S, Cameron JL, eds. Diseases of the Pancreas: Current Surgical Therapy. Heidelberg: Springer Inc, 2008;61:695-704
The researchers discovered that, while there was a similar rate of pancreatic cancer in older Americans, rates of the disease in women under the age of 55 rose 2.4% higher than the rates of ...
Pancreatic cancer has a poor prognosis, [2] with a five-year survival rate of less than 5%. By the time the cancer is diagnosed, it is usually at an advanced, inoperable stage. [9] Only one in about fifteen to twenty patients is curative surgery attempted. [11] Pancreatic cancer tends to be aggressive, and it resists radiotherapy and ...