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2. ACSL4 - Wikipedia

   en.wikipedia.org/wiki/ACSL4

   The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity , subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters , and thereby play a key role in lipid biosynthesis and ...

3. Long-chain 3-hydroxyacyl-coenzyme A dehydrogenase deficiency

   en.wikipedia.org/wiki/Long-chain_3-hydroxyacyl...

   As a result, these fatty acids are not converted to energy, which can lead to characteristic features of this disorder, such as lethargy and hypoglycemia. Long-chain fatty acids or partially metabolized fatty acids may build up in tissues and damage the liver, heart, retina, and muscles, causing more serious complications.

4. Long-chain-aldehyde dehydrogenase - Wikipedia

   en.wikipedia.org/wiki/Long-chain-aldehyde_de...

   ALDH3A2 catalyzes the oxidation of long-chain aliphatic aldehydes into fatty acids. It is known to act on a variety of both saturated and unsaturated aliphatic aldehydes between 6 and 24 carbons in length, as well as dihydrophytal, a 20-carbon branched chain aldehyde. [6] It requires NAD+ as a co-factor.

5. Very long-chain acyl-coenzyme A dehydrogenase deficiency

   en.wikipedia.org/wiki/Very_long-chain_acyl...

   As a result, these fatty acids are not converted into energy, which can lead to characteristic signs and symptoms of this disorder, such as lethargy and hypoglycemia. Levels of very long-chain fatty acids or partially degraded fatty acids may build up in tissues and can damage the heart, liver, and muscles, causing more serious complications.

6. CYP4A11 - Wikipedia

   en.wikipedia.org/wiki/CYP4A11

   The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and hydroxylates medium-chain fatty acids such as laurate and myristate. [6] CYP4A11 is highly expressed in the liver and kidney. [7]

7. Very long-chain acyl-CoA synthetase - Wikipedia

   en.wikipedia.org/wiki/Very_long-chain_acyl-CoA_s...

   The protein encoded by this gene is an isozyme of long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters , and thereby play a key role in lipid biosynthesis and fatty ...