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Sulfasalazine metabolizes to sulfapyridine. Serum levels should be monitored every three months, and more frequently at the outset. Serum levels above 50 μg/L are associated with side effects. In rare cases, sulfasalazine can cause severe depression in young males. It can also cause oligospermia and temporary infertility.
Sulfonamide is a functional group (a part of a molecule) that is the basis of several groups of drugs, which are called sulphonamides, sulfa drugs or sulpha drugs. The original antibacterial sulfonamides are synthetic antimicrobial agents that contain the sulfonamide group.
Serious side effects include agranulocytosis, aplastic anaemia, hypersensitivity reactions (like anaphylaxis and bronchospasm), toxic epidermal necrolysis and it may provoke acute attacks of porphyria, as it is chemically related to the sulfonamides.
Sulfonylureas — effects enhanced; Phenytoin, half-life of phenytoin is increased; Antifolates like pyrimethamine, proguanil and methotrexate increase the risk of associated side effects like bone marrow toxicity, folic acid supplementation should be considered. A significant risk of megaloblastic anaemia exists with doses of pyrimethamine in ...
Megaloblastic anaemia; Methaemoglobinaemia; Erythema multiforme; Low blood sugar; Hepatitis (liver swelling); Crystalluria (crystals in the urine); Urinary obstruction causing difficulty passing urine
Having ED is a common problem that both older men and younger men in the United States experience. In fact, some research indicates that 30 million American men experience symptoms of ED — and ...
Pairing a retinol with an ultra hydrating night cream, like RoC Retinol Correxion Deep Wrinkle Anti-Aging Night Cream, is a good way to make sure that hydrating ingredients balance out the intense ...
Common side effects include nausea and loss of appetite. [6] Other side effects include liver inflammation, methemoglobinemia, [7] and a number of types of skin rashes. [4] While the safety of use during pregnancy is not entirely clear some physicians recommend that it be continued in those with leprosy. [4] It is of the sulfone class. [4]