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Oligodendrocytes are a type of glial cell, non-neuronal cells in the central nervous system.They arise during development from oligodendrocyte precursor cells (OPCs), [8] which can be identified by their expression of a number of antigens, including the ganglioside GD3, [9] [10] [11] the NG2 chondroitin sulfate proteoglycan, and the platelet-derived growth factor-alpha receptor subunit (PDGF ...
Oligodendrocyte progenitor cells (OPCs), also known as oligodendrocyte precursor cells, NG2-glia, O2A cells, or polydendrocytes, are a subtype of glia in the central nervous system named for their essential role as precursors to oligodendrocytes and myelin. [1] They are typically identified in the human by co-expression of PDGFRA and CSPG4.
Only the resident oligodendrocyte precursor cells seem to keep this ability once the nervous system matures. Glial cells are known to be capable of mitosis . By contrast, scientific understanding of whether neurons are permanently post-mitotic , [ 28 ] or capable of mitosis, [ 29 ] [ 30 ] [ 31 ] is still developing.
The crystal structure of myelin oligodendrocyte glycoprotein was determined by x-ray diffraction at a resolution of 1.45 Angstroms, using protein from the Norway rat. This protein is 139 residues long, and is a member of the immunoglobulin superfamily. [13]
Cytoplasmic granules contain undigested remnants of mitochondrial structures. These contents include heme-linked copper and iron atoms remaining from mitochondrial enzymes. [ 73 ] These chemical substances account for the pseudoperoxidase activity of Gomori-positive granules that can utilized to stain for these granules.
Microglia in this state are able to search for and identify immune threats while maintaining homeostasis in the CNS. [18] [19] [20] Although this is considered the resting state, microglia in this form are still extremely active in chemically surveying the environment. Ramified microglia can be transformed into the activated form at any time in ...
The following other wikis use this file: Usage on ar.wikipedia.org جهاز عصبي مركزي; ميالين; إعادة تكون الميالين
18377 Ensembl n/a ENSMUSG00000049612 UniProt P23515 Q63912 RefSeq (mRNA) NM_002544 NM_019409 RefSeq (protein) NP_002535 NP_062282 Location (UCSC) n/a Chr 11: 79.39 – 79.39 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Oligodendrocyte-myelin glycoprotein is a protein that in humans is encoded by the OMG gene. See also Oligodendrocyte Myelin Glycoprotein References ^ a b c GRCm38 ...