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External dose quantities used in radiation protection and dosimetry. To enable consideration of stochastic health risk, calculations are performed to convert the physical quantity absorbed dose into equivalent dose, the details of which depend on the radiation type.
Animal models are used to learn more about a disease, its diagnosis and its treatment, with animal models predicting human toxicity in up to 71% of cases. [1] The human equivalent dose (HED) or human equivalent concentration (HEC) is the quantity of a chemical that, when administered to humans, produces an effect equal to that produced in test animals by a smaller dose. [2]
An equianalgesic chart is a conversion chart that lists equivalent doses of analgesics (drugs used to relieve pain). Equianalgesic charts are used for calculation of an equivalent dose (a dose which would offer an equal amount of analgesia) between different analgesics. [1]
External radiation protection dose quantities in SI units Graphic showing relationship of SI radiation dose units. To enable consideration of stochastic health risk, calculations are performed to convert the physical quantity absorbed dose into equivalent and effective doses, the details of which depend on the radiation type and biological ...
The deterministic effects that can lead to acute radiation syndrome only occur in the case of high doses (> ~10 rad or > 0.1 Gy) and high dose rates (> ~10 rad/h or > 0.1 Gy/h). A model of deterministic risk would require different weighting factors (not yet established) than are used in the calculation of equivalent and effective dose.
D = Φ × conversion coefficient for absorbed dose. The driver for this is the need to measure the deterministic effect, which it is suggested, is more appropriate than stochastic effect. This would calculate equivalent dose quantities H lens and H skin. This would remove the need for the ICRU Sphere and the Q-L function.
That model calculates an effective radiation dose, measured in units of rem, which is more representative of the stochastic risk than the absorbed dose in rad. In most power plant scenarios, where the radiation environment is dominated by X-or gamma rays applied uniformly to the whole body, 1 rad of absorbed dose gives 1 rem of effective dose. [5]
Another use is in the therapeutic drug monitoring of drugs with a narrow therapeutic index. For example, gentamicin is an antibiotic that can be nephrotoxic (kidney damaging) and ototoxic (hearing damaging); measurement of gentamicin through concentrations in a patient's plasma and calculation of the AUC is used to guide the dosage of this drug ...