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Peak-to-trough ratio in pharmacokinetics is the ratio of peak (C max) and trough (C min) levels of a drug over its dosing interval (τ) at steady state.. Peak-to-trough ratio (PTR), also known as peak-to-trough variation or peak-to-trough fluctuation, is a parameter in pharmacokinetics which is defined as the ratio of C max (peak) concentration and C min (trough) concentration over a dosing ...
A risk–benefit ratio (or benefit-risk ratio) is the ratio of the risk of an action to its potential benefits. Risk–benefit analysis (or benefit-risk analysis) is analysis that seeks to quantify the risk and benefits and hence their ratio. Analyzing a risk can be heavily dependent on the human factor.
English: A rational scale to assess the harm of drugs. Data source is the March 24, 2007 article: Nutt, David, Leslie A King, William Saulsbury, Colin Blakemore. "Development of a rational scale to assess the harm of drugs of potential misuse" The Lancet 2007; 369:1047-1053.
Suppose that we wish to compare the drug of interest to a class of drugs, for which nausea was reported as an adverse event 1489 times, out of 53789 total adverse events reported for drugs in the class. Thus, nausea was reported with proportion 1489 / 53789 = 0.028 for the class of drugs. The PRR in this case is 0.061 / 0.028 = 2.18.
The risk difference (RD), excess risk, or attributable risk [1] is the difference between the risk of an outcome in the exposed group and the unexposed group. It is computed as I e − I u {\displaystyle I_{e}-I_{u}} , where I e {\displaystyle I_{e}} is the incidence in the exposed group, and I u {\displaystyle I_{u}} is the incidence in the ...
This value is very useful in determining the therapeutic benefit or risk to patients in experimental groups, in comparison to patients in placebo or traditionally treated control groups. [citation needed] Three statistical terms rely on EER for their calculation: absolute risk reduction, relative risk reduction and number needed to treat.
Similarly, attributable risk percent (ARP) is used as a synonym for the attributable risk percent among the exposed. [ 3 ] In climatology , fraction of attributable risk (FAR) is used to denote a proportion of adverse event risk attributable to the human influence on climate or other forcing factor.
Quantitatively, it is the ratio given by the toxic dose divided by the therapeutic dose. A protective index is the toxic dose of a drug for 50% of the population (TD 50) divided by the minimum effective dose for 50% of the population (ED 50). A high protective index is preferable to a low one: this corresponds to a situation in which one would ...