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High doses of vitamin B-12, such as those used to treat a deficiency, might cause: Headache; Nausea and vomiting; Diarrhea; Fatigue or weakness; Tingling sensation in hands and feet
Too much B12 is probably a common health condition that mostly affects people taking over-the-counter or prescription vitamin B12 supplements. Most people taking too much B12 will probably not experience symptoms. Early signs of too much B12 include mild diarrhea and itching.
In most countries, the lower vitamin B12 range of what’s considered normal levels is too low (100-250), often missing severe deficiencies. People show signs of B12 deficiency even at higher levels, as deficiencies may begin to appear in the cerebrospinal fluid below 550.
Summary: High Vitamin B12 Levels. To sum up, are your vitamin B12 levels too high? Your first priority is to rule out any underlying conditions, such as kidney failure, liver disease, or cancer, which can release B12 back into the blood. Early diagnosis is key, so if you have excess B12 levels, get tested.
The most common cause of high B12 in the blood is due to recent ingestion or injection of supplemental vitamin B12. We don't worry about overdosing on B12 supplements because excess can be excreted in your urine.
Depending on the cause of your high B12, your symptoms may be related to an underlying condition. Still, high doses of B12 via supplements or injections may cause temporary symptoms. Dizziness, anxiety, headache and nausea are potential signs of elevated B12 levels, Mayo Clinic reports.
Naturally high levels of vitamin B12 may be an early sign of a serious, even life-threatening, disease. It can point to liver disease, diabetes, or certain types of leukemia.
Serum vitamin B12 mean levels were 312.36 and 284.31 pmol/L for women and men respectively (p < 0.001). Deficiency prevalence was greater for men (25.5%) in comparison with women (18.9%; p < 0.001). Men were strongly associated with severe deficiency. Vitamin B12 Deficiency and the Role of Gender.
For reference, the recommended daily intake (RDI) of vitamin B12 is 2.4 mcg for both men and women, though pregnant and breastfeeding women have a higher need . Summary
Vitamin B12 levels are higher, generally 50–500 mcg, in supplements containing vitamin B12 with other B-complex vitamins and even higher, typically 500–1,000 mcg, in supplements containing only vitamin B12. The most common form of vitamin B12 in dietary supplements is cyanocobalamin [1, 3, 23, 24].